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KMID : 1161420140170121383
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Journal of Medicinal Food
2014 Volume.17 No. 12 p.1383 ~ p.1385
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Agaricus bisporus Attenuates Dextran Sulfate Sodium-Induced Colitis
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Um Min-Young
Park Jae-Ho
Gwon So-Young
Ahn Ji-Yun
Jung Chang-Hwa
Ha Tae-Youl
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Abstract
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Agaricus bisporus (white button mushroom, WBM) is widely consumed in most countries and is reported to have anti-inflammatory and antioxidant activities. However, little is known regarding its effects in dextran sulfate sodium (DSS)-induced colitis, which are related to dysfunction of intestinal immunity. The aim of the present study was to investigate the effects of WBMs in an animal model of DSS-induced colitis. Male, 4-week-old ICR mice (n=10 per group) were fed a normal diet with or without 10% WBM for 4 weeks, and colitis was induced by 3% DSS in drinking water for 7 days. WBMs prevented DSS-induced shortening of colon length (P=.033) and diminished diarrhea (P=.049) and gross bleeding (P=.001), resulting in a decreased disease activity index. Results of histological analysis showed that WBMs suppressed mucosal damage. In addition, WBMs attenuated the DSS-induced increase in myeloperoxidase activity (P=.012) and upregulation of proinflammatory cytokine tumor necrosis factor-α (P=.020) in the colon segment. Taken together, these findings suggest a possible role for the WBM as an immunomodulator that can prevent and/or treat ulcerative colitis.
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KEYWORD
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Agaricus bisporus, colitis, dextran sulfate sodium, inflammation
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